Endocrine Abstracts

Background: Osteogenesis imperfecta (OI) is a heritable disease of the connective tissues caused primarily by heterogeneous mutations in the genes encoding for type I collagen. Phenotypically, it is characterized by abnormal bone mineralization, tissue fragility, and skeletal deformities.Objective: The aim of this study was to investigate the osteoclastogenic potential of unfractionated peripheral blood mononuclear cells (PBMCs) from OI patients (mean ag...

Background: Obesity and in particular visceral adiposity has been related to low bone mineral density (BMD) and greater fracture risk. Subjects with Prader–Willi syndrome (PWS) have lower amount of visceral fat than patients with simple obesity, however can develop osteoporosis. A strong relationship between inhibition of the osteoblast formation and induction of the adipocyte differentiation has been demonstrated. Inhibitors of osteoblastogenesis, such as Dickkopf-1 (DKK...

Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease and Post-surgical HypoPT (PS-HypoPT) is the most common cause, caused by accidental parathyroid injury. From a neuropsychological standpoint, patients with PS-HypoPT present cognitive and neuropsychological symptoms. Irisin is a myokine secreted by contracting muscle, which mediates beneficial effects on several targets, including brain. The aim of this study was to evaluate irisin in the context of PS-HypoP...

Introduction: Cerebral palsy (CP) is the most common chronic disability in childhood, burden by motor, sensation, cognition, feeding and communication impairment. A serious concern in children with CP is bone/muscle health deterioration, which negatively impacts the already reduced quality of life (QoL). Irisin is a myokine secreted by contracting muscle, which mediates beneficial effects on several targets, including brain. The aim of this pilot study was to evaluate serum le...